INSIST

IN Silico clinical trials for Ischemic STroke

Publications

publication list alphabetical

Click on the title to go to the paper

  1. Arrarte Terreros N, Bruggeman AAE, Swijnenburg ISJ, van Meenen LCC, Groot AE, Coutinho JM, Roos YBWEM, Emmer BJ, Beenen LFM, van Bavel E, Marquering HA, Majoie CBLM. Early recanalization in large-vessel occlusion stroke patients transferred for endovascular treatment. J Neurointerv Surg. 2022 May;14(5):480–4. doi: 10.1136/neurintsurg-2021-017441. Epub 2021 May 13. PMID: 33986112; PMCID: PMC9016237.
  2. Arrarte Terreros N, Bruggeman AAE, van Voorst H, et al. Bifurcation occlusions and endovascular treatment outcome in acute ischemic stroke. Journal of NeuroInterventional Surgery Published Online First: 22 March 2022. doi: 10.1136/neurintsurg-2021-018560.
  3. Arrarte Terreros N, Tolhuisen ML, Bennink E, de Jong HWAM, Beenen LFM, Majoie CBLM, van Bavel E, Marquering HA. From perviousness to permeability, modelling and measuring intra-thrombus flow in acute ischemic stroke. J Biomech. 2020 Oct 9;111:110001. doi: 10.1016/j.jbiomech.2020.110001. Epub 2020 Aug 21. PMID: 32896744.
  4. Arrarte Terreros N, van Willigen BG, Niekolaas WS, Tolhuisen ML, Brouwer J, Coutinho JM, Beenen LF, Majoie CB, van Bavel E, Marquering HA. Occult blood flow patterns distal to an occluded artery in acute ischemic stroke. J Cereb Blood Flow Metab. 2022 Feb;42(2):292-302. doi: 10.1177/0271678X211044941. Epub 2021 Sep 22. PMID: 34550818; PMCID: PMC8795216.
  5. Berti F, Bridio S, Luraghi G, Pant S, Allegretti D, Pennati G, Petrini L. Reliable Numerical Models of Nickel-Titanium Stents: How to Deduce the Specific Material Properties from Testing Real Devices. Ann Biomed Eng. 2022 Apr;50(4):467-481. doi: 10.1007/s10439-022-02932-1. Epub 2022 Feb 25. PMID: 35212855; PMCID: PMC8917046.
  6. Boodt N, Compagne KCJ, Dutra BG, Samuels N, Tolhuisen ML, Alves HCBR, Kappelhof M, Lycklama À Nijeholt GJ, Marquering HA, Majoie CBLM, Lingsma HF, Dippel DWJ, van der Lugt A; Coinvestigators MR CLEAN Registry. Stroke Etiology and Thrombus Computed Tomography Characteristics in Patients With Acute Ischemic Stroke: A MR CLEAN Registry Substudy. Stroke. 2020 Jun;51(6):1727-1735. doi: 10.1161/STROKEAHA.119.027749. Epub 2020 May 14. PMID: 32404040.
  7. Boodt N, Snouckaert van Schauburg PRW, Hund HM, Fereidoonnezhad B, McGarry JP, Akyildiz AC, van Es ACGM, De Meyer SF, Dippel DWJ, Lingsma HF, van Beusekom HMM, van der Lugt A, Gijsen FJH. Mechanical Characterization of Thrombi Retrieved With Endovascular Thrombectomy in Patients With Acute Ischemic Stroke. Stroke. 2021 Aug;52(8):2510-2517. doi: 10.1161/STROKEAHA.120.033527. Epub 2021 Jun 3. PMID: 34078112; PMCID: PMC8312567.
  8. Bridio S, Luraghi G, Rodriguez Matas JF, Dubini G, Giassi GG, Maggio G, Kawamoto JN, Moerman KM, McGarry P, Konduri PR, Arrarte Terreros N, Marquering HA, van Bavel E, Majoie CBLM, Migliavacca F. Impact of the Internal Carotid Artery Morphology on in silico Stent-Retriever Thrombectomy Outcome. Front Med Technol. 2021 Aug 3;3:719909. doi: 10.3389/fmedt.2021.719909. PMID: 35047950; PMCID: PMC8757691.
  9. Cahalane R, Boodt N, Akyildiz AC, Giezen JA, Mondeel M, van der Lugt A, Marquering H, Gijsen F. A review on the association of thrombus composition with mechanical and radiological imaging characteristics in acute ischemic stroke. J Biomech. 2021 Dec 2;129:110816. doi: 10.1016/j.jbiomech.2021.110816. Epub 2021 Oct 15. PMID: 34798567.
  10. Dwivedi A, Glynn A, Johnson S, Duffy S, Fereidoonnezhad B, McGarry P, Gilvarry M, McCarthy R; INSIST investigators. Measuring the effect of thrombosis, thrombus maturation and thrombolysis on clot mechanical properties in an in-vitro model. J Biomech. 2021 Dec 2;129:110731. doi: 10.1016/j.jbiomech.2021.110731. Epub 2021 Sep 6. PMID: 34601216.
  11. El-Bouri WK, MacGowan A, Józsa TI, Gounis MJ, Payne SJ. Modelling the impact of clot fragmentation on the microcirculation after thrombectomy. PLoS Comput Biol. 2021 Mar 12;17(3):e1008515. doi: 10.1371/journal.pcbi.1008515. PMID: 33711015; PMCID: PMC7990195.
  12. El-Bouri, Wahbi & Bing, Yun & Józsa, Tamás & Payne, S. (2019). A novel multi-scale, multi-compartment model of oxygen transport – Towards in-silico clinical trials in the entire human brain.
  13. Fereidoonnezhad B, Dwivedi A, Johnson S, McCarthy R, McGarry P. Blood clot fracture properties are dependent on red blood cell and fibrin content. Acta Biomater. 2021 Jun;127:213-228. doi: 10.1016/j.actbio.2021.03.052. Epub 2021 Mar 31. PMID: 33812070.
  14. Fereidoonnezhad B, McGarry P. A new constitutive model for permanent deformation of blood clots with application to simulation of aspiration thrombectomy. J Biomech. 2022 Jan;130:110865. doi: 10.1016/j.jbiomech.2021.110865. Epub 2021 Nov 12. PMID: 34839150.
  15. Fereidoonnezhad B, Moerman KM, Johnson S, McCarthy R, McGarry PJ. A new compressible hyperelastic model for the multi-axial deformation of blood clot occlusions in vessels. Biomech Model Mechanobiol. 2021 Aug;20(4):1317-1335. doi: 10.1007/s10237-021-01446-4. Epub 2021 Apr 5. PMID: 33818678.
  16. Fereidoonnezhad B, O’Connor C, McGarry JP. A new anisotropic soft tissue model for elimination of unphysical auxetic behaviour. J Biomech. 2020 Oct 9;111:110006. doi: 10.1016/j.jbiomech.2020.110006. Epub 2020 Aug 28. PMID: 32927115.
  17. Georgakopoulou T, van der Wijk AE, Bakker ENTP, vanBavel E; INSIST investigators. Quantitative 3D analysis of tissue damage in a rat model of microembolization. J Biomech. 2021 Nov 9;128:110723. doi: 10.1016/j.jbiomech.2021.110723. Epub 2021 Sep 2. PMID: 34509910.
  18. Georgakopoulou T, van der Wijk AE, Bakker ENTP, vanBavel E; INSIST investigators. Recovery of Hypoxic Regions in a Rat Model of Microembolism. J Stroke Cerebrovasc Dis. 2021 Jun;30(6):105739. doi: 10.1016/j.jstrokecerebrovasdis.2021.105739. Epub 2021 Mar 23. Erratum in: J Stroke Cerebrovasc Dis. 2021 Nov;30(11):105967. PMID: 33765634.
  19. Graff BJ, Payne SJ, El-Bouri WK. The Ageing Brain: Investigating the Role of Age in Changes to the Human Cerebral Microvasculature With an in silico Model. Front Aging Neurosci. 2021 Aug 5;13:632521. doi: 10.3389/fnagi.2021.632521. PMID: 34421568; PMCID: PMC8374868.
  20. Hund H, Boodt N, Arrarte Terreros N, Taha A, Marquering HA, van Es ACGM, Bokkers RPH, Lycklama À Nijeholt GJ, Majoie CBLM, Dippel DWJ, Lingsma HF, van Beusekom HMM, van der Lugt A; MR CLEAN Registry Investigators. Quantitative thrombus characteristics on thin-slice computed tomography improve prediction of thrombus histopathology: results of the MR CLEAN Registry. Eur Radiol. 2022 Apr 30. doi: 10.1007/s00330-022-08762-y. Epub ahead of print. PMID: 35501573.
  21. Johnson S, McCarthy R, Gilvarry M, McHugh PE, McGarry JP. Investigating the Mechanical Behavior of Clot Analogues Through Experimental and Computational Analysis. Ann Biomed Eng. 2021 Jan;49(1):420-431. doi: 10.1007/s10439-020-02570-5. Epub 2020 Jul 20. PMID: 32691265.
  22. Józsa TI, Padmos RM, El-Bouri WK, Hoekstra AG, Payne SJ. On the Sensitivity Analysis of Porous Finite Element Models for Cerebral Perfusion Estimation. Ann Biomed Eng. 2021 Dec;49(12):3647-3665. doi: 10.1007/s10439-021-02808-w. Epub 2021 Jun 21. PMID: 34155569; PMCID: PMC8671295.
  23. Józsa TI, Padmos RM, Samuels N, El-Bouri WK, Hoekstra AG, Payne SJ. A porous circulation model of the human brain for in silico clinical trials in ischaemic stroke. Interface Focus. 2021 Feb 6;11(1):20190127. doi: 10.1098/rsfs.2019.0127. Epub 2020 Dec 11. PMID: 33343874; PMCID: PMC7739914.
  24. Konduri PR, Marquering HA, van Bavel EE, Hoekstra A, Majoie CBLM; INSIST Investigators. In-Silico Trials for Treatment of Acute Ischemic Stroke. Front Neurol. 2020 Sep 16;11:558125. doi: 10.3389/fneur.2020.558125. PMID: 33041995; PMCID: PMC7525145.
  25. Konduri P, van Kranendonk K, Boers A, Treurniet K, Berkhemer O, Yoo AJ, van Zwam W, van Oostenbrugge R, van der Lugt A, Dippel D, Roos Y, Bot J, Majoie C, Marquering H; MR CLEAN Trial Investigators (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands). The Role of Edema in Subacute Lesion Progression After Treatment of Acute Ischemic Stroke. Front Neurol. 2021 Jul 20;12:705221. doi: 10.3389/fneur.2021.705221. PMID: 34354669; PMCID: PMC8329530.
  26. Luraghi G, Bridio S, Rodriguez Matas JF, Dubini G, Boodt N, Gijsen FJH, van der Lugt A, Fereidoonnezhad B, Moerman KM, McGarry P, Konduri PR, Arrarte Terreros N, Marquering HA, Majoie CBLM, Migliavacca F; INSIST investigators. The first virtual patient-specific thrombectomy procedure. J Biomech. 2021 Sep 20;126:110622. doi: 10.1016/j.jbiomech.2021.110622. Epub 2021 Jul 10. PMID: 34298290.
  27. Luraghi G, Bridio S, Miller C, Hoekstra A, Rodriguez Matas JF, Migliavacca F. Applicability analysis to evaluate credibility of an in silico thrombectomy procedure. J Biomech. 2021 Sep 20;126:110631. doi: 10.1016/j.jbiomech.2021.110631. Epub 2021 Jul 12. PMID: 34298293.
  28. Luraghi G, Cahalane RME, van de Ven E, Overschie SCM, Gijsen FJH, Akyildiz AC. In vitro and in silico modeling of endovascular stroke treatments for acute ischemic stroke. J Biomech. 2021 Oct 11;127:110693. doi: 10.1016/j.jbiomech.2021.110693. Epub 2021 Aug 14. PMID: 34450517.
  29. Luraghi G, Rodriguez Matas JF, Dubini G, Berti F, Bridio S, Duffy S, Dwivedi A, McCarthy R, Fereidoonnezhad B, McGarry P, Majoie CBLM, Migliavacca F; INSIST investigators. Applicability assessment of a stent-retriever thrombectomy finite-element model. Interface Focus. 2021 Feb 6;11(1):20190123. doi: 10.1098/rsfs.2019.0123. Epub 2020 Dec 11. PMID: 33343873; PMCID: PMC7739910.
  30. Migliavacca F, Luraghi G, Akyildiz AC, Gijsen FJH. Thrombus mechanics: How can we contribute to improve diagnostics and treatment? J Biomech. 2022 Feb;132:110935. doi: 10.1016/j.jbiomech.2021.110935. Epub 2021 Dec 23. PMID: 35026650.
  31. Francesco Migliavacca, Is modeling stents still an important issue? Procedia structural Integrity, Volume 15, 2019, Pages 46-50, ISSN 2452-3216, https://doi.org/10.1016/j.prostr.2019.07.009.
  32. Miller C, Padmos RM, van der Kolk M, Józsa TI, Samuels N, Xue Y, Payne SJ, Hoekstra AG. In silico trials for treatment of acute ischemic stroke: Design and implementation. Comput Biol Med. 2021 Oct;137:104802. doi: 10.1016/j.compbiomed.2021.104802. Epub 2021 Aug 26. PMID: 34520989.
  33. Miller, C., van der Kolk, M., Padmos, R., Józsa, T., Hoekstra, A. (2021). Uncertainty Quantification of Coupled 1D Arterial Blood Flow and 3D Tissue Perfusion Models Using the INSIST Framework. In: Paszynski, M., Kranzlmüller, D., Krzhizhanovskaya, V.V., Dongarra, J.J., Sloot, P.M.A. (eds) Computational Science – ICCS 2021. ICCS 2021. Lecture Notes in Computer Science(), vol 12747. Springer, Cham. https://doi.org/10.1007/978-3-030-77980-1_52
  34. Moerman KM, Konduri P, Fereidoonnezhad B, Marquering H, van der Lugt A, Luraghi G, Bridio S, Migliavacca F, Rodriguez Matas JF, McGarry P. Development of a patient-specific cerebral vasculature fluid-structure-interaction model. J Biomech. 2022 Mar;133:110896. doi: 10.1016/j.jbiomech.2021.110896. Epub 2022 Jan 7. PMID: 35124518.
  35. Moerman, KM Behrooz Fereidoonnezhad, J. Patrick McGarry. Novel hyperelastic models for large volumetric deformations. International Journal of Solids and Structures, Volumes 193–194, 2020. Pages 474-491, ISSN 0020-7683, https://doi.org/10.1016/j.ijsolstr.2020.01.019.
  36. Padmos RM, Józsa TI, El-Bouri WK, Konduri PR, Payne SJ, Hoekstra AG. Coupling one-dimensional arterial blood flow to three-dimensional tissue perfusion models for in silico trials of acute ischaemic stroke. Interface Focus. 2021 Feb 6;11(1):20190125. doi: 10.1098/rsfs.2019.0125. Epub 2020 Dec 11. PMID: 33335706; PMCID: PMC7739918.
  37. Padmos RM, Terreros NA, Józsa TI, Závodszky G, Marquering HA, Majoie CBLM, Hoekstra AG. Modelling the leptomeningeal collateral circulation during acute ischaemic stroke. Med Eng Phys. 2021 May;91:1-11. doi: 10.1016/j.medengphy.2021.03.003. Epub 2021 Mar 17. PMID: 34074460.
  38. Petkantchin R, Padmos R, Boudjeltia KZ, Raynaud F, Chopard B; INSIST investigators. Thrombolysis: Observations and numerical models. J Biomech. 2022 Feb;132:110902. doi: 10.1016/j.jbiomech.2021.110902. Epub 2021 Dec 24. PMID: 34998180.
  39. Petkantchin, R., Raynaud, F., Boudjeltia, K.Z., Chopard, B. (2024). A Blood Flow Modeling Framework for Stroke Treatments. In: Heifetz, A. (eds) High Performance Computing for Drug Discovery and Biomedicine. Methods in Molecular Biology, vol 2716. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3449-3_17
  40. Remy Petkantchin, Alexandre Rousseau, Omer Eker, Karim Zouaoui Boudjeltia, Franck Raynaud, Bastien Chopard & the INSIST investigators. A simplified mesoscale 3D model for characterizing fibrinolysis under flow conditions. Scientific Reports volume 13, Article number: 13681 (2023).|https://doi.org/10.1038/s41598-023-40973-1
  41. Raynaud F, Rousseau A, Monteyne D, Perez-Morga D, Zouaoui Boudjeltia K, Chopard B. Investigating the two regimes of fibrin clot lysis: an experimental and computational approach. Biophys J. 2021 Sep 21;120(18):4091-4106. doi: 10.1016/j.bpj.2021.08.005. Epub 2021 Aug 10. PMID: 34384765; PMCID: PMC8510862.
  42. Samuels N, van de Graaf RA, van den Berg CAL, Nieboer D, Eralp I, Treurniet KM, Emmer BJ, Immink RV, Majoie CBLM, van Zwam WH, Bokkers RPH, Uyttenboogaart M, van Hasselt BAAM, Mühling J, Burke JF, Roozenbeek B, van der Lugt A, Dippel DWJ, Lingsma HF, van Es ACGM; MR CLEAN Registry Investigators. Blood Pressure During Endovascular Treatment Under Conscious Sedation or Local Anesthesia. Neurology. 2021 Jan 12;96(2):e171-e181. doi: 10.1212/WNL.0000000000011006. Epub 2020 Oct 7. PMID: 33028664; PMCID: PMC7905780.
  43. Samuels N, van de Graaf RA, van den Berg CAL, Uniken Venema SM, Bala K, van Doormaal PJ, van der Steen W, Witvoet E, Boiten J, den Hertog H, Schonewille WJ, Hofmeijer J, Schreuder F, Schreuder TAHCML, van der Worp HB, Roos YBWEM, Majoie CBLM, Burke JF, van Es ACGM, van der Lugt A, Roozenbeek B, Lingsma HF, Dippel DWJ; MR CLEAN Registry Investigators. Blood Pressure in the First 6 Hours Following Endovascular Treatment for Ischemic Stroke Is Associated With Outcome. Stroke. 2021 Nov;52(11):3514-3522. doi: 10.1161/STROKEAHA.120.033657. Epub 2021 Sep 20. PMID: 34538090; PMCID: PMC8547588.
  44. Shibeko AM, Chopard B, Hoekstra AG, Panteleev MA. Redistribution of TPA Fluxes in the Presence of PAI-1 Regulates Spatial Thrombolysis. Biophys J. 2020 Aug 4;119(3):638-651. doi: 10.1016/j.bpj.2020.06.020. Epub 2020 Jun 26. PMID: 32653051; PMCID: PMC7399491.
  45. Staessens S, De Meyer SF. Thrombus heterogeneity in ischemic stroke. Platelets. 2021 Apr 3;32(3):331-339. doi: 10.1080/09537104.2020.1748586. Epub 2020 Apr 20. PMID: 32310709.
  46. Staessens S, Denorme F, Francois O, Desender L, Dewaele T, Vanacker P, Deckmyn H, Vanhoorelbeke K, Andersson T, De Meyer SF. Structural analysis of ischemic stroke thrombi: histological indications for therapy resistance. Haematologica. 2020 Jan 31;105(2):498-507. doi: 10.3324/haematol.2019.219881. PMID: 31048352; PMCID: PMC7012484.
  47. Staessens S, Fitzgerald S, Andersson T, Clarençon F, Denorme F, Gounis MJ, Hacke W, Liebeskind DS, Szikora I, van Es A, Brinjikji W, Doyle KM, De Meyer SF. Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations. Int J Stroke. 2020 Jul;15(5):467-476. doi: 10.1177/1747493019884527. Epub 2019 Nov 3. PMID: 31679478.
  48. Staessens S, François O, Brinjikji W, Doyle KM, Vanacker P, Andersson T, De Meyer SF. Studying Stroke Thrombus Composition After Thrombectomy: What Can We Learn? Stroke. 2021 Nov;52(11):3718-3727. doi: 10.1161/STROKEAHA.121.034289. Epub 2021 Sep 14. PMID: 34517770; PMCID: PMC8545837.
  49. Staessens S, François O, Desender L, Vanacker P, Dewaele T, Sciot R, Vanhoorelbeke K, Andersson T, De Meyer SF. Detailed histological analysis of a thrombectomy-resistant ischemic stroke thrombus: a case report. Thromb J. 2021 Feb 22;19(1):11. doi: 10.1186/s12959-021-00262-1. PMID: 33618719; PMCID: PMC7901204.
  50. van der Wijk AE, Georgakopoulou T, Majolée J, van Bezu JSM, van der Stoel MM, van Het Hof BJ, de Vries HE, Huveneers S, Hordijk PL, Bakker ENTP, van Bavel E. Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain. Acta Neuropathol Commun. 2020 Nov 17;8(1):195. doi: 10.1186/s40478-020-01071-9. PMID: 33203478; PMCID: PMC7671188.
  51. van der Wijk AE, Lachkar N, de Vos J, Grootemaat AE, van der Wel NN, Hordijk PL, Bakker ENTP, vanBavel E. Extravasation of Microspheres in a Rat Model of Silent Brain Infarcts. Stroke. 2019 Jun;50(6):1590-1594. doi: 10.1161/STROKEAHA.119.024975. Epub 2019 Apr 18. PMID: 31136287.
  52. Xue Y, El-Bouri WK, Józsa TI, Payne SJ. Modelling the effects of cerebral microthrombi on tissue oxygenation and cell death. J Biomech. 2021 Oct 11;127:110705. doi: 10.1016/j.jbiomech.2021.110705. Epub 2021 Aug 23. Erratum in: J Biomech. 2022 May;136:111070. PMID: 34464872.