In silico models of perfusion defects and tissue damage

 

Objectives

1. Modelling of microvascular and tissue damage post-occlusion.

2. Multi-scale modelling of the relation of vascular occlusion by thrombi with microvasculature impairment;

3. Validation through data from literature and from imaging and experimental data;

4. Provide high-scale models of tissue damage as input for in silico clinical stroke trials describing tissue damage as a function of time from stroke onset-to-recanalization/reperfusion.