INSIST paper accepted! AMC team and coworkers published a paper on extravasation of micro-emboli in Stroke and made it to the front cover.

cover stroke

A paper on the structural features in thrombi has just been published (06-05-2019)!



May 2018, The INSIST project was presented by Praneeta Konduri at the 4th European Stroke Organisation Conference in Gotenborg, Sweden:



INSIST work has already presented at various (inter)national congresses, follow the link when you want to know where..

At the 8th World Congress of Biomechanics, 9 July, 2018 in Dublin Ireland, Praneeta Konduri presented the INSIST project in an oral presentation titled: "INSIST – IN Silico trials for treatment of acute Ischemic STroke"




INSIST Clinical Focus Group Discussions at INSIST All hands workshop Milan – a Whitepaper

April, 4 & 5, 2019

Matthew Gounis1, Ana Paula Narata2, Luca Valvassori3, Aad van der Lugt4, Hester Lingsma5, Laurian Jongejan6, Vanessa Blanc-Guillemaud7, Yvo Roos8, Diederik Dippel9, Alfons Hoekstra10, Ed van Bavel11, Henk Marquering11, 12, Charles Majoie12.

1 Department of Radiology, University of Massachusetts, Worcester, Massachusetts, USA.

2 Department of Neuroradiology, Bretonneau Hospital, University of Tours, Tours, France

3 Department of Neuroradiology, San Gerardo Hospital, Monza, Italy

4 Department of Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands

5 Department of Public Health, Erasmus MC University Medical Center, Rotterdam, the Netherlands

6 Department of Experimental Immunology, Amsterdam University Medical Centers, location AMC, Amsterdam, the Netherlands

7 Institut de Recherche International Servier, Suresnes, France

8 Department of Neurology, Amsterdam University Medical Centers, location AMC, Amsterdam, the Netherlands

9 Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands

10 Computational Science Lab, Faculty of Science, Institute for Informatics, University of Amsterdam, Amsterdam, Netherlands

11 Biomedical Engineering, Amsterdam University Medical Centers, location AMC, Amsterdam

12 Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, location AMC, Amsterdam, the Netherlands


In silico clinical trials hold the promise to use computational modelling of disease and its treatment to support the evaluation and introduction of new drugs and medical devices. The INSIST (In silico clinical trials for treatment of ischemic stroke) project aims to develop an in silico platform for the simulation and evaluation of novel treatments for acute ischemic stroke. INSIST comprises the generation of virtual patient populations, the in silico modeling of brain tissue death due to the lack of oxygen and nutrients following a stroke, thrombosis and thrombolysis, and thrombectomy. The combination allows in silico simulation of (pre-) clinical trials. The INSIST project organizes Focus Group Discussions involving specific stakeholders and contributors. In April 2019 Clinical Focus Group Discussions were organized to inform interested clinicians and to obtain their feedback on the concept, current state of the art, and intended further development of the INSIST project. In short, the concept of in silico stroke trials was considered promising, especially the thrombectomy modeling was regarded valuable. The modeling of tissue death and its effect on clinical outcome was considered the most complex and risky.

Read the whole paper here

INSIST postdoctoral fellow at Oxford Wahbi El-Bouri wrote an article arch 2019 for the Brain Awareness Week in Oxford. The Brain awareness week is an annual global initiative designed to raise awareness among the public about brain-related research and the impact that neuroscientists are having on the world. Read the article here