INSIST young investigators presented their results at the CompBioMed conference in London 2019. 



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Wahbi El-Bouri  (from Stephen Payne's group) presented WP5 work at the BRAIN & BRAIN PET 2019 conference (Yokohama, Japan,


    (photo courtesy of Kirsty Jean Grant)

INSIST work has already presented at various (inter)national congresses, follow the link when you want to know where..


INSIST paper accepted! AMC team and coworkers published a paper on extravasation of micro-emboli in Stroke and made it to the front cover.

Click here to read the paper!

cover stroke





INSIST Clinical Focus Group Discussions at INSIST All hands workshop Milan – a Whitepaper


In silico clinical trials hold the promise to use computational modelling of disease and its treatment to support the evaluation and introduction of new drugs and medical devices. The INSIST (In silico clinical trials for treatment of ischemic stroke) project aims to develop an in silico platform for the simulation and evaluation of novel treatments for acute ischemic stroke. INSIST comprises the generation of virtual patient populations, the in silico modeling of brain tissue death due to the lack of oxygen and nutrients following a stroke, thrombosis and thrombolysis, and thrombectomy. The combination allows in silico simulation of (pre-) clinical trials. The INSIST project organizes Focus Group Discussions involving specific stakeholders and contributors. In April 2019 Clinical Focus Group Discussions were organized to inform interested clinicians and to obtain their feedback on the concept, current state of the art, and intended further development of the INSIST project. In short, the concept of in silico stroke trials was considered promising, especially the thrombectomy modeling was regarded valuable. The modeling of tissue death and its effect on clinical outcome was considered the most complex and risky.

Read the whole paper here


A paper on the structural features in thrombi has been published (06-05-2019)!

Click here to read the paper


May 2018, The INSIST project was presented by Praneeta Konduri at the 4th European Stroke Organisation Conference in Gotenborg, Sweden: